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Luc Faucher, Andrée-Anne Guay-Bégin, Jean Lagueux, Marie-France Côté, Éric Petitclerc and Marc-André Fortin Ultra-small gadolinium oxide nanoparticles to image brain cancer cells in vivo with MRI Contrast Media & Molecular Imaging 6

Version of Record online: 1 DEC 2010 | DOI: 10.1002/cmmi.420

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Ultra-small paramagnetic gadolinium oxide nanoparticles (US-Gd2O3; 2-3nm nanocrystal diameter) can be used to label glioblastoma multiforme brain cancer cells, which appear positively contrasted in MR, T1-weighted images. High amounts of gadolinium are ingested in the cells, as confirmed by ICP-MS and transmission electron microscopy. The cells are then clearly visualized in vivo using the chicken embryo chorioallantoic membrane assay, a clinical MRI system and a common 3D T1-weighted spin-echo sequence. Images are free of susceptibility artifacts.

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