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Yuguo Li, Vipul R. Sheth, Guanshu Liu and Mark D. Pagel A self-calibrating PARACEST MRI contrast agent that detects esterase enzyme activity Contrast Media & Molecular Imaging 6

Version of Record online: 30 NOV 2010 | DOI: 10.1002/cmmi.421

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A PARACEST MRI contrast agent has been developed that is responsive to esterase enzyme activity. De-esterification and lactonization cause the appearance of an “enzymeresponsive” CEST effect from an amine group. A second “control” CEST effect can be detected before and after enzyme catalysis, so that this contrast agent is self-calibrating.

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