Carmen Burtea, Sophie Laurent, Isabelle Mahieu, Lionel Larbanoix, Alain Roch, Marc Port, Olivier Rousseaux, Sébastien Ballet, Oltea Murariu, Gérard Toubeau, Claire Corot, Luce Vander Elst and Robert N. Muller In vitro biomedical applications of functionalized iron oxide nanoparticles, including those not related to magnetic properties Contrast Media & Molecular Imaging 6
The goal of the present work was to develop and validate various in vitro biomedical applications of ultrasmall superparamagnetic particles of iron oxide (USPIO). USPIO coated with dextran, starch, or bisphosphonate exposing carboxylate groups were synthesized and some of them were functionalized by conjugating various biomolecules, such as biotin, streptavidin, and apoptosis, or VCAM-1 specific peptides. Our results confirm that rapid and simple in vitro detection of a diversity of functionalized USPIO with relevance in medicine is possible by the existing NMR techniques and by chemical staining reactions.
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