Lara Leoni, Anita Dhyani, Patrick La Riviere, Stefan Vogt, Barry Lai and B. B. Roman β-Cell subcellular localization of glucose-stimulated Mn uptake by X-ray fluorescence microscopy: implications for pancreatic MRI Contrast Media & Molecular Imaging 6
Subcellular uptake of manganese in MIN-6 insulinoma β-cells was visualized and quantified via X-ray fluorescence microscopy following exposure to 50 µ m MnCl2. Significant increase in manganese was measured under baseline 2 m m glucose conditions and more significantly at activating 16 m m glucose and at 16 m m glucose + 30 m m KCl media formulations. Intracellular manganese distribution changed with its increasing concentration and shifted from homogeneous throughout the whole cell to mainly cytoplasmic.
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