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Luigi Granato, Sophie Laurent, Luce Vander Elst, Kristina Djanashvili, Joop A. Peters and Robert N. Muller The Gd3+ complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono(p-isothiocyanatoanilide) conjugated to inulin: a potential stable macromolecular contrast agent for MRI Contrast Media & Molecular Imaging 6

Version of Record online: 29 NOV 2011 | DOI: 10.1002/cmmi.448

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Upon conjugation of Gd3+ complex of DOTA-NCSA with the modified polysaccharide inulin (L-API), the longitudinal relaxivity increases from 4.1 to 21.7 s−1 m m−1 at 20 MHz and 37 °C, thanks to efficient slowing down of the molecular tumbling of the Gd-chelate by the inulin carrier. The resulting conjugate shows an extremely high kinetic stability. No transmetalation with Zn2+ ions was observed.

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