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Ren-Yen Lin, Kasala Dayananda, Ting-Jung Chen, Chiao-Yun Chen, Gin-Chung Liu, Kun-Liang Lin and Yun-Ming Wang Targeted RGD nanoparticles for highly sensitive in vivo integrin receptor imaging Contrast Media & Molecular Imaging 7

Article first published online: 30 JAN 2012 | DOI: 10.1002/cmmi.457

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The USPIO nanoparticles surface is modified with mPPDA-silane and then conjugated with RGD. The in vitro and in vivo MR imaging studies are performed to evaluate targeting specificity and to differentiate the expression level of integrin receptor. This result implices that the RGD nanoparticles, which greatly enhance the MR imaging, are sufficiently sensitive to detect a tumor at an early stage.

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