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Osasere M. Evbuomwan, Matthew E. Merritt, Garry E. Kiefer and A. Dean Sherry Nanoparticle-based PARACEST agents: the quenching effect of silica nanoparticles on the CEST signal from surface-conjugated chelates Contrast Media & Molecular Imaging 7

Article first published online: 30 JAN 2012 | DOI: 10.1002/cmmi.459

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CEST signal of EuDOTA–(gly)4− is quenched upon conjugation to the surface of silica nanoparticles partially due to rapid prototropic exchange catalyzed by charged groups on the nanoparticle surface.

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