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Bo Zhang, Biao Jiang, Ying Chen, Hai Huang, Qiuping Xie, Muxing Kang, Hui Zhang, Chuanxin Zhai and Yulian Wu Detection of viability of transplanted beta cells labeled with a novel contrast agent – polyvinylpyrrolidone-coated superparamagnetic iron oxide nanoparticles by magnetic resonance imaging Contrast Media & Molecular Imaging 7

Article first published online: 17 FEB 2012 | DOI: 10.1002/cmmi.461

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We used self-synthesied pvp-SPIO to label beta-cell line or islets. We observed our PVP-SPIO displayed good biocompatibility and magnetic properties, and possessed superior labeling efficiency than Feridex. There existed correlation between the number of labeled cells and R2 value on MRI. The signal intensity and the intracellular iron content also well correlated with the viability of labeled cells. The signal intensity on MRI might be useful predictor to evaluate the number and the viability of labeled cells.

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