Michael Hodenius, Christian Würth, Jabadurai Jayapaul, John E. Wong, Twan Lammers, Jessica Gätjens, Susanne Arns, Natascha Mertens, Ioana Slabu, Gergana Ivanova, Jörg Bornemann, Marcel De Cuyper, Ute Resch-Genger and Fabian Kiessling Fluorescent magnetoliposomes as a platform technology for functional and molecular MR and optical imaging Contrast Media & Molecular Imaging 7
The fluorophore-normalized fluorescence, quantum yields and fluorescence lifetimes of rhodamine B-containing fluorescent magnetoliposomes (FLU-ML) were substantially reduced by inner filter effects as the magnetoliposome concentration was increased, by increasing molar rhodamine B fraction, and by quenching originating from the iron oxide cores. However, the internalized FLU-ML in human prostata carcinoma cells were clearly visible by fluorescence microscopy. At the FLU-ML concentrations used (up to 3 × 10−3 M Fe), cell viability was not substantially impaired.
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