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Anke de Vries, Maarten B. Kok, Honorius M. H. F. Sanders, Klaas Nicolay, Gustav J. Strijkers and Holger Grüll Multimodal liposomes for SPECT/MR imaging as a tool for in situ relaxivity measurements Contrast Media & Molecular Imaging 7

Article first published online: 30 JAN 2012 | DOI: 10.1002/cmmi.468

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We propose a multimodal radiolabeled paramagnetic liposomal contrast agent for simultaneous imaging with SPECT and MRI. As SPECT-based quantification allows determination of the gadolinium concentration, the MRI signal can be deconvoluted to derive the net contrast agent relaxivity. The latter provides indirect information about the intracellular location of the multimodal nanoparticle as a reduced relaxivity indicates compartmentalization into cell organelles (i.e. endosomes).

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