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Eric Sabondjian, Andrea J. Mitchell, Gerald Wisenberg, James White, Kimberley J. Blackwood, Jane Sykes, Lela Deans, Robert Z. Stodilka and Frank S. Prato Hybrid SPECT/cardiac-gated first-pass perfusion CT: locating transplanted cells relative to infarcted myocardial targets Contrast Media & Molecular Imaging 7

Article first published online: 30 JAN 2012 | DOI: 10.1002/cmmi.469

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A challenge with cardiac cell therapy is determining the location of cells relative to the region of reduced perfusion in the myocardium. We have developed a novel imaging technique by sequentially acquiring 111In-labeled cell information and first-pass perfusion CT information using the Siemens Symbia-T6 SPECT/CT system to obtain a single fused image displaying both sets of information. We have shown that this is an effective hybrid platform for the localization of cells in relation to the area of reduced perfusion.

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