Luca Menichetti, Francesca Frijia, Alessandra Flori, Florian Wiesinger, Vincenzo Lionetti, Giulio Giovannetti, Giovanni Donato Aquaro, Fabio A. Recchia, Jan Henrik Ardenkjaer-Larsen, Maria Filomena Santarelli and Massimo Lombardi Assessment of real-time myocardial uptake and enzymatic conversion of hyperpolarized [1-13C]pyruvate in pigs using slice selective magnetic resonance spectroscopy Contrast Media & Molecular Imaging 7
Hyperpolarized 13C-MRS can potentially become a powerful tool to study the physiology of organs such as the heart, through the quantification of kinetic patterns under pathophysiological conditions. In this study we assessed myocardial uptake and metabolism of hyperpolarized [1-13C]pyruvate in anesthetized pigs during dobutamine-induced stimulation. We detected an increase of the apparent kinetic constants for bicarbonate and lactate of two fold during dobutamine infusion: these data parallel with the Rate Pressure Product, an indirect parameter of cardiac oxygen consumption.
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