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Piper J. Klemm, William C. Floyd III, Danil E. Smiles, Jean M. J. Fréchet and Kenneth N. Raymond Improving T1 and T2 magnetic resonance imaging contrast agents through the conjugation of an esteramide dendrimer to high-water-coordination Gd(III) hydroxypyridinone complexes Contrast Media & Molecular Imaging 7

Version of Record online: 30 JAN 2012 | DOI: 10.1002/cmmi.483

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Hexadentate 1,4,7-triazacyclonane (TACN) capped Gd-hydroxypyridinone (HOPO) complexes with 2 or 3 sites open for water coordination have been synthesized. These complexes have been conjugated via peptide bond formation to a 40 kDa degradable esteramide (EA) dendrimer to increase relaxivity (to r1 = 31 mM-1s-1, r2 = 52 mM-1s-1 at 60 MHz and 37 °C), solubility, and biocompatibility.

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