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Jonathan L. Hecht, Ellen E. Sheets and Kenneth R. Lee Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations Cancer Cytopathology 96

Version of Record online: 1 FEB 2002 | DOI: 10.1002/cncr.10312

Over a 3-year period, 18% fewer thin-layer preparations were interpreted as atypical glandular cells of undetermined significance (AGUS), whereas the frequency of detection of a high-grade precursor lesion or carcinoma of either squamous or glandular type after an AGUS interpretation increased slightly relative to conventional cervical smears. These findings imply an increased diagnostic specificity of AGUS for a high-grade precursor lesion or carcinoma using thin-layer preparations.

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