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Rudolf Pihusch, Gudrun Danzl, Michael Scholz, Detlev Harich, Markus Pihusch, Peter Lohse and Erhard Hiller Impact of thrombophilic gene mutations on thrombosis risk in patients with gastrointestinal carcinoma Cancer 94

Article first published online: 12 JUN 2002 | DOI: 10.1002/cncr.10590

Heterozygosity for the thrombophilic mutation factor V Leiden proved to be a significant risk factor for tumor-associated thrombosis. Most thrombotic events occurred during the first few months after tumor diagnosis and in close correlation to the onset of chemotherapy, indicating that diagnostic and therapeutic procedures might play an additional role in the pathogenesis of thrombosis. Results also suggest that the prothrombin G20210A mutation might be a significant cofactor in cancer pathogenesis.

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