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Geza Acs, Paul J. Zhang, Timothy R. Rebbeck, Peter Acs and Ajay Verma Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma Cancer 95

Article first published online: 19 AUG 2002 | DOI: 10.1002/cncr.10787

Benign mammary epithelial cells and cells of in situ and invasive breast carcinomas express both erythropoietin (Epo) and Epo receptor (EpoR). Increased EpoR immunostaining in breast carcinomas is correlated with clinicohistopathologic features suggestive of an adverse prognosis. Increased autocrine Epo signaling may represent a novel mechanism by which hypoxia promotes breast carcinoma and induces a malignant phenotype.

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