The current study describes the results of a double blind, placebo-controlled, randomized, single crossover trial of the treatment of patients with postmastectomy lymphedema, using low-level laser therapy. Two cycles of laser treatment were found to significantly reduce affected limb volume, extracellular fluid, and tissue hardness in approximately 33% of participants 3 months after treatment. This result was significantly better than that achieved with one cycle of treatment, which was found to be no better than placebo.
