Lifen Ren-Heidenreich, Pamela A. Davol, Nicola M. Kouttab, Gerald J. Elfenbein and Lawrence G. Lum Redirected T-cell cytotoxicity to epithelial cell adhesion molecule-overexpressing adenocarcinomas by a novel recombinant antibody, E3Bi, in vitro and in an animal model Cancer 100
Article first published online: 26 JAN 2004 | DOI: 10.1002/cncr.20060
A novel, recombinant, chimeric-bispecific antibody, E3Bi, was developed in the authors' laboratory. In both in vitro and in vivo experiments, E3Bi demonstrated specific and effective antitumor effects in eradicating tumors that carried the tumor-associated antigen, epithelial cell adhesion molecule.
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