Jon M. Davison, Eli Rosenbaum, Terry L. Barrett, David Goldenberg, Mohammad O. Hoque, David Sidransky and William H. Westra Absence of V599E BRAF mutations in desmoplastic melanomas Cancer 103
Article first published online: 7 JAN 2005 | DOI: 10.1002/cncr.20861
The relative importance of BRAF mutational activation in melanocytic tumorigenesis was not the same across the various subtypes of melanoma, even for melanomas of cutaneous origin that are associated with sun exposure. In contrast to conventional cutaneous melanomas, the desmoplastic variant frequently did not harbor an activating mutation of BRAF.
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