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Sivan Elloul, Mari Bukholt Elstrand, Jahn M. Nesland, Claes G. Tropé, Gunnar Kvalheim, Iris Goldberg, Reuven Reich and Ben Davidson Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma Cancer 103

Version of Record online: 1 MAR 2005 | DOI: 10.1002/cncr.20946

The Snail, Slug, and Smad-interacting protein 1 (Sip1) transcription factors were expressed differentially in metastatic breast and ovarian carcinoma in effusions, such as the expression of E-cadherin and matrix metalloproteinase 2 in these tumor types. A higher Sip1/E-cadherin ratio was correlated with advanced disease and poor overall survival in patients with ovarian carcinoma, whereas higher Snail expression predicted poor progression-free and overall survival in patients with breast carcinoma.

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