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Melinda E. Sanders, Peggy A. Schuyler, William D. Dupont and David L. Page The natural history of low-grade ductal carcinoma in situ of the breast in women treated by biopsy only revealed over 30 years of long-term follow-up Cancer 103

Version of Record online: 9 MAY 2005 | DOI: 10.1002/cncr.21069

Small, low-grade, noncomedo ductal carcinoma in situ is the pivotal lesion in understanding the borderline between malignancy and nonmalignancy in the female breast. Noncomedo ductal carcinoma in situ is a nonobligate precursor that involves a very long clinical evolution to invasive carcinoma in approximately 50% of patients when excised incompletely.

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