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Yumi Yokoyama and Sundaram Ramakrishnan Addition of an aminopeptidase N-binding sequence to human endostatin improves inhibition of ovarian carcinoma growth Cancer 104

Article first published online: 10 JUN 2005 | DOI: 10.1002/cncr.21149

In the current study, the authors investigated whether the antiangiogenic activity of human endostatin could be improved by NGR motif-mediated targeting. NGR-endostatin showed increased binding of endostatin to endothelial cells, leading to improved antiangiogenic and tumor-inhibitory properties of endostatin.

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