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Franca Piras, Romano Colombari, Luigi Minerba, Daniela Murtas, Carlo Floris, Cristina Maxia, Arianna Corbu, M. Teresa Perra and Paola Sirigu The predictive value of CD8, CD4, CD68, and human leukocyte antigen-D-related cells in the prognosis of cutaneous malignant melanoma with vertical growth phase Cancer 104

Version of Record online: 2 AUG 2005 | DOI: 10.1002/cncr.21283

In the current study, the authors investigated the antitumoral activity of melanoma-infiltrating immune system cells and found a statistically significant, favorable correlation between survival and the density of primary tumor-infiltrating CD8 T lymphocytes or human leukocyte antigen-D-related cells. These results may be important for identifying additional prognostic factors with which to evaluate disease progression and develop immune therapies for patients with primary cutaneous melanoma.

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