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Timothy D. Jones, John N. Eble, Mingsheng Wang, Gregory T. MacLennan, Shashi Jain and Liang Cheng Clonal divergence and genetic heterogeneity in clear cell renal cell carcinomas with sarcomatoid transformation Cancer 104

Article first published online: 26 JUL 2005 | DOI: 10.1002/cncr.21288

Our molecular data suggest that both clear cell and sarcomatoid components of renal cell carcinomas are derived from the same progenitor cell. Different patterns of allelic loss in multiple chromosomal regions were observed in clear cell and sarcomatoid components from the same patient. This genetic heterogeneity indicates genetic divergence during the clonal evolution of renal cell carcinoma.

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