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Emer O. Hanrahan, Kristine R. Broglio, Aman U. Buzdar, Richard L. Theriault, Vicente Valero, Massimo Cristofanilli, Guosheng Yin, Shu-Wan C. Kau, Gabriel N. Hortobagyi and Edgardo Rivera Combined-modality treatment for isolated recurrences of breast carcinoma Cancer 104

Article first published online: 26 JUL 2005 | DOI: 10.1002/cncr.21305

Patients with an isolated recurrence of breast carcinoma that has been treated locally with surgical resection and/or irradiation with curative intent, such that there is no evidence of clinically measurable disease are classified as Stage IV—no evidence of disease (Stage IV-NED). Compared with historic controls, these patients demonstrated improved outcomes in Phase II studies if they received systemic chemotherapy after local treatment for their isolated recurrence. A proportion of these patients with Stage IV-NED breast carcinoma had prolonged disease-free and overall survival after chemotherapy, and the only significant independent prognostic factor was the number of involved axillary lymph nodes at initial diagnosis.

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