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Masanori Kaneuchi, Masahiro Sasaki, Yuichiro Tanaka, Hiroaki Shiina, Hideto Yamada, Ritsu Yamamoto, Noriaki Sakuragi, Hideki Enokida, Mukesh Verma and Rajvir Dahiya WT1 and WT1-AS genes are inactivated by promoter methylation in ovarian clear cell adenocarcinoma Cancer 104

Version of Record online: 30 AUG 2005 | DOI: 10.1002/cncr.21397

This study shows for the first time that expression or nonexpression of the Wilms tumor suppressor 1 gene (WT1) and WTI antisense (WT1-AS) genes is an important biochemical feature that distinguishes serous from clear cell ovarian adenocarcinoma, respectively. CpG hypermethylation of the WT1 and WT1-AS gene promoters is shown to be an important mechanism that leads to their inactivation in ovarian clear cell adenocarcinoma.

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