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Kui-Hin Liau, Leyo Ruo, Jinru Shia, Aasim Padela, Mithat Gonen, William R. Jarnagin, Yuman Fong, Michael I. D'Angelica, Leslie H. Blumgart and Ronald P. DeMatteo Outcome of partial hepatectomy for large (> 10 cm) hepatocellular carcinoma Cancer 104

Article first published online: 29 SEP 2005 | DOI: 10.1002/cncr.21415

Partial hepatectomy for large (> 10 cm) hepatocellular carcinoma (HCC) is believed by many to be ineffective. The authors compared outcomes after surgical resection of 82 patients with tumors >10 cm with 111 patients with smaller tumors. The 5-year overall survival for patients with large HCC was 33% with a median of 32 months and was similar in patients with smaller tumors. There also was no difference in operative mortality (2% in large HCC vs. 6%) or recurrence rate. Therefore, partial hepatectomy is safe for patients with large HCC and, in selected patients, achieves similar overall survival and recurrence-free survival.

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