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Tuya Pal, Jenny Permuth-Wey, Judith A. Betts, Jeffrey P. Krischer, James Fiorica, Hector Arango, James LaPolla, Mitchell Hoffman, Martin A. Martino, Katie Wakeley, George Wilbanks, Santo Nicosia, Alan Cantor and Rebecca Sutphen BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases Cancer 104

Version of Record online: 14 NOV 2005 | DOI: 10.1002/cncr.21536

In this population-based study of incident epithelial ovarian carcinomas, the authors demonstrated that the frequency of BRCA1 and BRCA2 mutations among women with ovarian carcinoma was higher than reported previously. The current data suggested that it may be reasonable to offer genetic counseling to any woman with invasive epithelial ovarian carcinoma, because family history is not sufficiently accurate to predict the presence or absence of a mutation.

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