Ayesha B. Alvero, David O'Malley, David Brown, Graham Kelly, Manish Garg, Wei Chen, Thomas Rutherford and Gil Mor Molecular mechanism of phenoxodiol-induced apoptosis in ovarian carcinoma cells Cancer 106
Article first published online: 30 DEC 2005 | DOI: 10.1002/cncr.21633
Phenoxodiol, a novel isoflavone derivative, sensitizes ovarian carcinoma cells to chemotherapeutic agents both in vitro and in vivo. In addition, it is able to induce apoptosis by activating the caspase-2-Bid signaling pathway and by promoting the proteasomal degradation of XIAP.
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