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Shehzad Basaria, Denis C. Muller, Michael A. Carducci, Josephine Egan and Adrian S. Dobs Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy Cancer 106

Article first published online: 30 DEC 2005 | DOI: 10.1002/cncr.21642

The authors evaluated the long-term effects of androgen-deprivation therapy (ADT) on fasting glucose levels and insulin resistance in men with prostate carcinoma (PCa) to determine whether these metabolic alterations were because of hypogonadism. The results suggested that men with PCa who received long-term ADT are at risk of developing insulin resistance and hyperglycemia, and may be predisposed to an increased risk of cardiovascular disease. These complications are directly attributable to hypogonadism.

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