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Roderick M. Quiros, Geetha Rao, Janet Plate, Jules E. Harris, Gregory J. Brunn, Jeffrey L. Platt, Paolo Gattuso, Richard A. Prinz and Xiulong Xu Elevated serum heparanase-1 levels in patients with pancreatic carcinoma are associated with poor survival Cancer 106

Article first published online: 30 DEC 2005 | DOI: 10.1002/cncr.21648

A novel enzyme-linked immunoadsorbent assay was developed to measure serum heparanase (HPR) activity. Serum HPR levels are elevated in pancreatic carcinoma patients and are correlated with heparanase expression in tumor tissue, and increased serum HPR1 levels are associated with a shorter survival.

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