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Robert M. Rifkin, Stephanie A. Gregory, Ann Mohrbacher and Mohamad A. Hussein Pegylated liposomal doxorubicin, vincristine, and dexamethasone provide significant reduction in toxicity compared with doxorubicin, vincristine, and dexamethasone in patients with newly diagnosed multiple myeloma Cancer 106

Article first published online: 10 JAN 2006 | DOI: 10.1002/cncr.21662

The regimen of pegylated liposomal doxorubicin, vincristine, and reduced-dose dexamethasone (DVd) was compared with vincristine, doxorubicin, and reduced-dose dexamethasone (VAd) for patients with newly diagnosed multiple myeloma and demonstrated similar efficacy with less toxicity and supportive care compared with VAd. The DVd regimen should improve clinical utility and potentially may optimize the opportunity for transplantation.

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