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Ji-Youn Han, Hyeong-Seok Lim, Dae Ho Lee, So Young Ju, Sung Young Lee, Hyae Young Kim, Yong-Hoon Park, Chun Gun Park and Jin Soo Lee Randomized Phase II study of two opposite administration sequences of irinotecan and cisplatin in patients with advanced nonsmall cell lung carcinoma Cancer 106

Version of Record online: 12 JAN 2006 | DOI: 10.1002/cncr.21668

The efficacy, toxicity, and pharmacokinetics of combined chemotherapy with irinotecan and cisplatin were evaluated according to administration sequence in chemotherapy-naive patients with nonsmall cell lung carcinoma. For future clinical use, the authors recommend administering cisplatin first and then irinotecan, because that sequence was associated with a higher response rate.

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