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Enzo Maria Ruggeri, Diana Giannarelli, Emilio Bria, Paolo Carlini, Alessandra Felici, Fabrizio Nelli, Michele Gallucci, Francesco Cognetti and Camillo Francesco Pollera Adjuvant chemotherapy in muscle-invasive bladder carcinoma Cancer 106

Article first published online: 17 JAN 2006 | DOI: 10.1002/cncr.21676

To date, the ‘gold standard’ treatment for muscle invasive bladder carcinoma has been recognized to be radical cystectomy. Adjuvant chemotherapy (AC) has the advantage of being administered to patients with known prognostic factors of recurrence. A pooled analysis was used to verify whether AC is able to increase the disease-free survival and overall survival of patients with muscle invasive bladder carcinoma who had undergone radical cystectomy. The results of the analysis of AC demonstrate that chemotherapy given to a subset of patients with known prognostic factors of recurrence can benefit both disease-free and overall survival by reducing the number of patients receiving an inferior treatment.

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