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Wilburn E. Reddick, Zuyao Y. Shan, John O. Glass, Susan Helton, Xiaoping Xiong, Shengjie Wu, Melanie J. Bonner, Scott C. Howard, Robbin Christensen, Raja B. Khan, Ching-Hon Pui and Raymond K. Mulhern Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia Cancer 106

Version of Record online: 12 JAN 2006 | DOI: 10.1002/cncr.21679

Neurocognitive tests of attention, intelligence, and academic achievement as well as quantitative magnetic resonance examinations of brain tissue volumes confirmed the hypothesis that survivors of childhood acute lymphoblastic leukemia have significant deficits in attention and that smaller white-matter volumes are associated directly with impaired neurocognitive performance. Cranial irradiation exacerbated these findings.

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