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William C. Chen, Andrew Jackson, Amy S. Budnick, David G. Pfister, Dennis H. Kraus, Margie A. Hunt, Hilda Stambuk, Sabine Levegrun and Suzanne L. Wolden Sensorineural hearing loss in combined modality treatment of nasopharyngeal carcinoma Cancer 106

Article first published online: 18 JAN 2006 | DOI: 10.1002/cncr.21683

A significant increase in risk of sensorineural hearing loss was found among patients receiving > 48 Gy to the cochlea, suggesting a threshold in radiation dose–response in the setting of combined modality therapy. This dose should serve as a cochlear mean dose constraint maximum for intensity-modulated radiotherapy treatment of nasopharynx carcinoma.

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