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Der-Cherng Liang, Lee-Yung Shih, Jen-Fen Fu, Huei-Ying Li, Hsiu-I Wang, Iou-Jih Hung, Chao-Ping Yang, Tang-Her Jaing, Shu-Huey Chen and Hsi-Che Liu K-ras mutations and N-ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements Cancer 106

Article first published online: 10 JAN 2006 | DOI: 10.1002/cncr.21687

In a large-scale study using direct sequencing for each polymerase chain reaction product, the authors documented the frequency of K-Ras and N-Ras mutations in childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia. K-Ras mutations were detected in 40% of patients who had ALL that was positive for mixed-lineage leukemia gene (MLL) rearrangements, a proportion that was significantly higher compared with that among patients who had MLL-negative B-precursor ALL.

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