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Cristian Massacesi, Salvatore Terrazzino, Fabiana Marcucci, Marco B. Rocchi, Paolo Lippe, Renato Bisonni, Marco Lombardo, Alberta Pilone, Rodolfo Mattioli and Alberta Leon Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy Cancer 106

Version of Record online: 2 FEB 2006 | DOI: 10.1002/cncr.21722

Uridine diphosphate glucuronosyl transferase (UGT1A1) polymorphism appears to be predictive of the risk of diarrhea, emesis, and fatigue caused by combination chemotherapy with irinotecan and raltitrexed. Screening for UGT1A1 promoter polymorphism may identify those patients at higher risk of severe toxicity after irinotecan-based chemotherapy.

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