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Grace C. H. Yang, Doreen Liebeskind and Albert V. Messina Diagnostic accuracy of follicular variant of papillary thyroid carcinoma in fine-needle aspirates processed by ultrafast Papanicolaou stain Cancer Cytopathology 108

Article first published online: 15 MAR 2006 | DOI: 10.1002/cncr.21837

Over a 11-year period, 125 histologic follow-ups were available for fine-needle aspirations reported as suspicious for follicular variant (FV) of papillary carcinoma (PC), based on follicles with “grape-like” watery clear nuclei in Ultrafast Papanicolaou stain. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy in the detection of PC were 93.6%, 94.9%, 93.6%, 94.9%, and 94.3%, respectively, when follicular adenomas containing atypical nuclei were counted as encapsulated FVPC; and were 92.6%, 85.6%, 80%, 94.9%, and 88.3%, respectively, when follicular adenomas containing atypical nuclei were counted as benign.

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