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Donald L. Trump, Douglas M. Potter, Josephia Muindi, Adam Brufsky and Candace S. Johnson Phase II trial of high-dose, intermittent calcitriol (1,25 dihydroxyvitamin D3) and dexamethasone in androgen-independent prostate cancer Cancer 106

Version of Record online: 5 APR 2006 | DOI: 10.1002/cncr.21890

Epidemiologic and preclinical data indicate that calcitriol may be important in controlling the growth of prostate cancer. A Phase II study in patients with androgen-independent prostate cancer, in which calcitriol at a dose of 12 μg was given Monday, Tuesday, and Wednesday weekly and dexamethasone at a dose of 4 mg was given Sunday, Monday, Tuesday, and Wednesday weekly, disclosed a prostate-specific antigen response rate of 19% and no limiting toxicity.

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