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Rehana L. Ahmed, Kathryn H. Schmitz, Kristin E. Anderson, Wayne D. Rosamond and Aaron R. Folsom The metabolic syndrome and risk of incident colorectal cancer Cancer 107

Version of Record online: 23 MAY 2006 | DOI: 10.1002/cncr.21950

By using data from a multicenter prospective cohort study in men and women, the authors observed a dose-response association between colorectal cancer incidence and the number of metabolic syndrome components (0-5 components) that were present at baseline (P for trend = .006) after multivariate adjustment; the multivariate-adjusted association of metabolic syndrome (≥3 components) with colorectal cancer had borderline significance in men (relative risk, 1.78; 95% confidence interval, 1.0-3.6) and was absent in women (relative risk, 1.01; 95% confidence interval, 0.5-2.0).

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