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Alfonso Quintas-Cardama, Ahmed Aribi, Jorge Cortes, Francis J. Giles, Hagop Kantarjian and Srdan Verstovsek Novel approaches in the treatment of systemic mastocytosis Cancer 107

Article first published online: 31 AUG 2006 | DOI: 10.1002/cncr.22187

It is believed that mutations in codon 816 of the Kit kinase domain play a crucial role in the pathogenesis of systemic mastocytosis (SM). A series of novel compounds with activity against this mutant kinase have widened greatly the therapeutic armamentarium for patients with SM.

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