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Shiladitya Sengupta, Susmita Chakrabarti, Anup Roy, Chinmay K. Panda and Susanta Roychoudhury Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype Cancer 109

Version of Record online: 11 JAN 2007 | DOI: 10.1002/cncr.22430

The results from this study implicated tobacco-dependent hypermethylation of the mismatch-repair genes human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2) in samples of leukoplakia, in squamous cell carcinoma of the head and neck, and in adjacent normal tissues. The results suggested that tobacco-addicted individuals are more susceptible to promoter hypermethylation of hMLH1 and hMSH2 and that such events in the normal squamous epithelium of the head and neck region may lead to microsatellite instability pathway-dependent tumorigenesis.

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