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Young Nyun Park, Masamichi Kojiro, Luca Di Tommaso, Amar P. Dhillon, Fukuo Kondo, Masayuki Nakano, Michiie Sakamoto, Neil D. Theise and Massimo Roncalli Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules Cancer 109

Version of Record online: 5 FEB 2007 | DOI: 10.1002/cncr.22460

Stromal invasion is 1 of the main features used to distinguish high-grade dysplastic nodules (DNs) from well-differentiated hepatocellular carcinomas (HCCs). In this study, the authors evaluated whether ductular reaction (DR) takes place around noninvasive hepatocellular nodules but not within the stroma contiguous to invasive HCC. DR characteristically was absent at the stromal invasive, leading edge of tumor cells in both minimally invasive HCCs and overtly invasive HCCs. The results indicated that DR/cytokeratin 7 immunostaining may help to identify small foci of invasion and to distinguish noninvasive, high-grade DNs from both minimally and overtly invasive HCCs.

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