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Zhihong Gong, James R. Hebert, Roberd M. Bostick, Zonglin Deng, Thomas G. Hurley, Dan A. Dixon, Daniela Nitcheva and Dawen Xie Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma Cancer 109

Version of Record online: 18 JAN 2007 | DOI: 10.1002/cncr.22469

The arginine (Arg) 261 glutamine (Gln) polymorphism in the 12-lipoxygenase (12-LOX) gene was associated with a decreased risk for colorectal adenoma, with particularly reduced risk for patients with a Gln variant allele who regularly took nonsteroidal anti-inflammatory drugs (Pinteraction = .02). However, there were no associations between either of the 2 polymorphisms in the 5-LOX gene and colorectal adenoma.

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