Edith J. Mensah-Osman, Dafydd G. Thomas, Michelle M. Tabb, Jose M. Larios, Dennis P. Hughes, Thomas J. Giordano, Michelle L. Lizyness, James M. Rae, Bruce Blumberg, Paul F. Hollenberg and Laurence H. Baker Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines Cancer 109
Version of Record online: 5 FEB 2007 | DOI: 10.1002/cncr.22479
Approximately 30% to 40% of all patients with osteosarcomas ultimately experience recurrence. The study investigated the hypothesis that the resistance of osteosarcoma to chemotherapy may be related to the expression of a pregnane xenobiotic receptor (PXR) variant protein and its role as the major inducer of P450 3A4 in these tumors.
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