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Margaret E. Wright, Jarmo Virtamo, Anne M. Hartman, Pirjo Pietinen, Brenda K. Edwards, Philip R. Taylor, Jussi K. Huttunen and Demetrius Albanes Effects of α-tocopherol and β-carotene supplementation on upper aerodigestive tract cancers in a large, randomized controlled trial Cancer 109

Article first published online: 30 JAN 2007 | DOI: 10.1002/cncr.22482

In a randomized trial conducted in 29,000 Finnish male smokers, supplementation with vitamin E and/or β-carotene did not reduce the overall incidence of or mortality from site-specific upper aerodigestive tract cancers. However, β-carotene supplementation may impact the incidence of some subtypes of laryngeal tumors.

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