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Gary H. Lyman, Leon E. Cosler, Nicole M. Kuderer and John Hornberger Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer Cancer 109

Version of Record online: 20 FEB 2007 | DOI: 10.1002/cncr.22506

The prognostic and predictive accuracy for distant recurrence-free survival using a 21-gene reverse-transcriptase polymerase chain reaction assay has been validated in 668 lymph node-negative, estrogen receptor-positive women with early-stage breast cancer. A decision analysis based on the validation studies demonstrates that use of the assay to guide treatment is potentially more efficacious and less costly than routine treatment with either tamoxifen alone or chemotherapy and tamoxifen.

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