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Girish S. Kulkarni, Gina Lockwood, Andrew Evans, Ants Toi, John Trachtenberg, Michael A. S. Jewett, Antonio Finelli and Neil E. Fleshner Clinical predictors of gleason score upgrading Cancer 109

Version of Record online: 11 MAY 2007 | DOI: 10.1002/cncr.22712

Patients with low-risk prostate cancer who have elevated PSA levels or who have had their prostate biopsy interpreted by a nonspecialist pathologist are at significantly higher risk of harboring occult high-grade disease and, thereby, potentially being undertreated. The authors present a nomogram (C statistic 0.71) that can help physicians risk-stratify patients with low-risk prostate cancer and subsequently facilitate appropriate treatment recommendations.

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