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Jonathan K. Armstrong, Georg Hempel, Susanne Koling, Linda S. Chan, Timothy Fisher, Herbert J. Meiselman and George Garratty Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients Cancer 110

Article first published online: 21 MAY 2007 | DOI: 10.1002/cncr.22739

Rapid clearance of poly(ethylene glycol)-asparaginase (PEG-ASNase) has been reported for up to one-third of patients treated for acute lymphoblastic leukemia. The presence of antibody specific to poly(ethylene glycol) was very closely associated with undetectable serum ASNase activity in PEG-ASNase-treated patients.

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